Thus, this symposium aims to gather a comprehensive functional understanding of mediator-dependent cellular and molecular events that are responsible for the plasticity of both stromal and tumor/stem cells. An absolute pre-requisite for such an endeavor is a comprehensive understanding of the exact molecular basis of the complex signaling networks in the tumor microenvironment that control the plasticity of both stromal and tumor cells, thereby shaping the complex cellular contexture, which ultimately forms a pro- or anti-tumorigenic milieu. Indeed, therapies that aim to shape the local immune milieu and consecutive signaling pathways in both stromal and tumor/stem cells address the complex pathophysiology of tumors more adequately and may therefore add substantial benefits for therapy. Composition and polarization of cells in the tumor microenvironment depends on genetic as well as environmental factors and is directly influenced by tumor therapy.
Finally, this conference ultimately seeks to promote ethically responsible and socially beneficial scientific research and technological innovation, and critical reflection about the influence of science, technology, and medicine on our values, culture, practices, and worldviews.During the last decade, it has become unequivocally evident that tumor development is not a cell-autonomous process but rather depends on the intricate reciprocal interplay of mutant tumor cells with their local and distant environments. From this background, presentations that explore the relationship between science and the public and the relationship between science and social justice are also included. The Conference features presentations that seek not only to understand how values and science have and do influence one another, but also how they must and should influence one another (as well as types of influence that should be avoided). The Values in Medicine, Science, and Technology Annual Conference seeks to explore the interplay between human, ethical, social, cultural, and political values, on the one hand, and science, technology, engineering, and medical research and practice, on the other hand.
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